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Research Histopathology
Research Histopathology

Research Lab Services

Toxicological studies
Our pathologists have many combined years of experience in reading tox studies. Since some strains of laboratory animals exhibit pathological conditions under normal circumstances, you don't want an inexperienced pathologist calling something wrong when it's actually normal. Our pathologists will compare your experimental animals to your control animals and report to you findings that are only important to your study. Our reports are also customized to your specific experiment. You tell us what you want looked at and we'll report only on the organs of your interest.

Types of Reports
We offer the researcher a variety of report formats to fit their individual needs:

DESCRIPTIVE: A descriptive pathology report is a narrative report in which the veterinary pathologist will describe, in detail, any abnormality (pathology) seen within the specimen on the microscope slide. This type of report is often used for diagnostic histopathology and efficacy results. Here is an example of a typical descriptive pathology report.

TOXICOLOGY: A toxicology report is a semi-quantitative pathology report in which the veterinary pathologist will review a set of target organs from groups of animals and report any abnormalities seen. Any pathological condition (inflammation, necrosis, fibrosis, etc.) is then scored on its severity (1 = mild to 3 = severe). This type of report is often used for the toxicity of a compound or efficacy results.

SEMI-QUANTITATIVE: A semi-quantitative pathology report is a pathology report in which the veterinary pathologist will review a set of specimens and score specific conditions specific to the client's research. Each criteria (inflammation, necrosis, fibrosis, etc.) is scored on its severity (1 = mild to 3 = severe). This type of report is often used for efficacy studies.

QUANTITATIVE: A quantitative pathology report is a report in which the veterinary pathologist will utilize computer-generated digital images of the client’s slides. Using various filters and colors, certain cell types can be isolated and quantified for exact quantities. For example, quantitative reports can obtain percentages (“12% of the total tissue mass consists of fibrosis”) or sizes (“The average islet size seen within this pancreas measures 84 microns in diameter and range from 24 to 197 microns in diameter”). This type of report is often used for very accurate measurements and not just ranges.

COMPREHENSIVE: A comprehensive pathology report is a report in which the veterinary pathologist will provide the researcher with a descriptive report which also includes semi-quantitative data, data analysis, annotated photographs and conclusions. This type of report is often requested for GLP studies.

CUSTOM: If none of the above reports fits your needs, Mass Histology Service will custom make a report which will answer all of your questions. For example, we have combined descriptive and semi-quantitative reports as seen in this example. We will work with you and come up with any type of report

GLP studies
MHS has the capabilities of receiving, processing, sectioning, staining and supplying you with a complete GLP-compliant histopathology report. All of our SOPs are signed "Master Documents" which are controlled and updated by our in-house QA officer, all work is performed by fully trained (and documented) technicians, daily temperatures, maintenance records and lot numbers are documented and archived and all regulatory forms are completed and maintained for each individual project.