Mass Histology Service, Inc.
A complete GLP-compliant histopathology Lab

Introducing our revolutionary new Tier Pricing System:

Once again, MHS breaks new ground by offering our clients even more ways to control how much you spend on your histology budget.  For the first time anywhere, we are offering a tier pricing structure in which YOU choose how much you spend:

STANDARD rates.  Not in a hurry?  Choose our standard service which includes our routine turn-around time and prices that are some of the lowest on Earth.  All work is performed "first come, first served" but because of the popularity of these prices, standard sized projects can take from several weeks to up to a month or more (especially large projects) to complete.

Today's standard turn-around is estimated to be 4 weeks

PRIORITY rates.  In a rush or have a small job?  Choose our priority service which puts your project next in line (kind of like "cutsies" way back when).  With this service, we try to get your slides back to you within 2 weeks of receipt.  Of course, this depends on how many RUSH cases are in front of your order.  Please don't call and ask for a definite date you'll get your slides.  One large RUSH case can set back your priority order by a few days to up to a week!  (Hint:  these prices are still below national averages).

RUSH rates.  You need it yesterday?  Choose our rush service if you need your work finished as soon as possible.  We will literally drop what we are doing and put our entire workforce on your project.  Depending on the size of your project or stains requested, we try to get routine-sized projects back to you within a few days (week-ends and holidays not included).  RUSH cases are also performed "first come, first served", so there are never any guarantees on exact turn-arounds.

Another way of saving money is by doing some of the work yourself.  The more work you do, the more money you save.  We can process the specimen and cut and stain the slides for you, we can process the specimen and cut the slides for you to stain yourself or we can process the specimen for you to cut and stain.  You tell us what you want and we'll do it for you.

NOTE:  All cassettes must be identified and all specimens must be sent to us in accordance with State, Federal and MHS regulations.  Please read and follow the few important instructions as outlined on our SENDING SPECIMENS page.


What $6.25 will get you at Mass Histology Service:

  • Processing of your cassette through alcohols, xylenes and into paraffin.

  • Embedding of the specimen into paraffin blocks.

  • Microtomy of the specimen at 5 microns in thickness, artifact free.

  • Placement of the cut section onto a SuperFrost glass slide.

  • Quality controlled, H&E staining of the section.

  • Coverslipping of the stained section with a glass coverslip.

  • Identification of the slide with a computer-generated label.

  • An invoice that will bring a smile to your face


Pricing:
These extraordinary low prices do not include return postage or slide boxes
also
MHS has a $100.00 minimum order limit which covers all administrative, technical and packaging costs

Histo Techniques:
  Standard Priority RUSH
Decalcification, small specimen $6.50
Decalcification, large specimen $15.00
Multiple tissue or large specimen surcharge (per our discretion) $2.50
Paraffin process ONLY
  Prepared from tissue submitted in a cassette $5.00 $7.50 $10.00
  Prepared from trimmed tissue (we supply the cassette) $6.50 $9.75 $13.00
   Prepared from un-trimmed tissue (we dissect and supply the cassette) $8.00 $12.00 $16.00
Process and embed cell suspension (double embed in agarose) $15.00 $22.50 $30.00

Paraffin process with one (1) H&E-stained slide

  Prepared from tissue submitted in a cassette $6.25 $9.35 $12.50
  Prepared from trimmed tissue (we supply the cassette) $7.75 $11.65 $15.50
  Prepared from un-trimmed tissue (we dissect and supply the cassette) $9.00 $13.50 $18.00
Other paraffin options
  Additional H&E-stained slide from faced block $3.60 $5.40 $7.20
  Additional un-stained slide from faced block $2.10 $3.15 $4.20
  H&E-stained slide prepared from submitted paraffin block $5.00 $7.50 $10.00
  H&E-stained an un-stained slide $1.50 $2.25 $3.00

Frozen sections

  Prepare, set-up and "face" into OCT block $8.00 $12.00 $16.00
  Un-stained section (1 section per slide) $2.50 $3.75 $5.00
  Additional un-stained section, same level placed on same slide $1.00 $1.50 $2.00
  Additional un-stained section, deeper level, new slide $2.50 $3.75 $5.00
  H&E-stain an un-stained slide $1.50 $2.25 $3.00

Special stains (priced per slide):

  Standard Priority RUSH
  Non-silver dye stains (Fe, trichrome, elastic, mast cell, PAS, congo red, etc.) 1 or 2 slides:  $25.00

More than 2 slides : $9.00 each

1 or 2 slides:  $38.00

More than 2 slides: $12.50 each

1 or 2 slides:  $50.00

More than 2 slides: $18.00 each

  Silver stains 1 or 2 slides:  $35.00

More than 2 slides: $15.00 each

1 or 2 slides:  $52.50

More than 2 slides: $22.50 each

1 or 2 slides:  $70.00

More than 2 slides: $30.00 each

  Immunohistochemistry (primary antibody provided by investigator). $25.00 $37.50 $50.00
  IHC Discovery Services (new antibody work-up) $425 $640 $850

Digital Photography

  Standard Priority RUSH
  Macro or Micro $12.00 $18.00

$24.00

  Annotated photographs $50.00 $75.00 $100.00

Necropsies

 Small animals delivered live to our facilities:  Euthanized, perfused, full necropsy, phlebotomy (red and purple top), body and major organ weights, photograph, decalcification, cassette tissue sections, gross notes, etc. $95.00 ea
 Small animals delivered fixed to our facilities:  Full necropsy, decal bones, cassette tissue sections, gross notes, etc. $75.00 ea
 On site necropsy service (within our service area)  We are fully insured $95.00 / hr

Histopathology reports
 (performed by a board-certified veterinary pathologist):

  Diagnostic pathology report, first site $39.00
  Diagnostic pathology report, additional site(s) $19.00
  Cytology (smears) $25.00
  Descriptive pathology report, per section $32.00
  Toxicology pathology report, per section $12.00
  Semi-quantitative pathology report, first parameter $12.00
  Semi-quantitative pathology report, Add'l parameters $8.00 ea
   

Comprehensive pathology reports
 (A complete, multi-page report written and signed by a licensed veterinary pathologist.  This report includes descriptive paragraphs about the gross and microscopic aspects of each specimen with tables, charts, graphs, annotated photographs, data analysis, comments, findings, summarizations and conclusions.):

  Based on client's choices inquire

NOTE:

Pathology report fees do not include the preparation of the microscope slide.

"Dissection" is defined as anytime a scalpel is used during processing of tissue.  Large specimens will be billed by $95.00 per hour.

A 20% surcharge plus audit fees is added to all GLP work ($1,000 minimum).

Prices do not include slide storage/transport boxes, packaging and postage or dry ice (if needed)


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H&E slides:

Although often referred to as the "routine" H&E (hematoxylin and eosin), staining a section of tissue with the H&E stain is far from being routine.  Solutions have to be fresh, quality control has to be meticulous and knowledge of ultrastructures is a must.  A properly stained tissue section with H&E will demonstrate all cytoplasmic and nuclear structures within the limit of the light microscope.
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Special stains:

The cost of special staines include microtomy of a paraffin block, staining, coverslipping and labeling of the slide.  Positive control slides are included with each batch of special stains.

some non-silver special stains include:

Acid Fast Stain (for mycobacteria)
Alcian Blue Stain
Alcian Blue-PAS Stain (PAB)
Congo Red Stain
Elastic van Gieson Stain
Giemsa (Modified May-Gruenwald) Stain (for hematopoietic tissues)
Giemsa Stain (for Helicobacter)
Gram (Modified Brown-Brenn) Stain
Iron Stain (Prussian blue)
Luxol Fast Blue (LFB) Stain
Mucicarmine Stain
Periodic acid-Schiff Stain (PAS)
Periodic acid-Schiff, digested Stain (PAS-D)
PTAH Stain
Trichrome Stain - Masson's method
Toluidine Blue Stain (for mast cells)

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some silver-based special stains include:


Bielschowsky Stain (for senile plaques)
Bodian's Stain
Fontana-Masson Stain for melanin
Grocott's Methenamine Silver (GMS) Stain
Jones' Silver Stain
Reticulin Stain
Spirochete Stain (Steiner & Steiner method)
VonKossa Stain for calcium

Most other stains (or variations of) can be performed.  Just ask us about your favorites.
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Immunochemistry

We can perform just about any antibody stain available for paraffin sections. Custom staining is one of our specialties. Our fees are $25.00 per slide.  Positive and negative controls are always run with each set of slides.  There is no charge for antigen retrieval, secondary antibody, strep-aviden, DAB and counterstaining.  The investigator supplies us only with the primary antibody.  We also provide immunohistochemistry discovery services which include a combination of at least 12 variables along with negative controls.  Batch-run discounts are also available.  Please e-mail us for specifics.
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Please contact us for further information.

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