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Contract Research Organizations
Clinical Research Organizations

(CRO's) Contract Research Organizations

Histolopathology Services:  Mass Histology Service, Inc. will work you from experiment conception to completion.  We have helped researchers with projects ranging from simple toxicity studies, to pilot efficacy studies to large GLP studies.  We never consider any project to be too small or too large.  Utalizing our one-on-one services, the investigator can call us at any time to discuss their potential or ongoing project and we will advise and assist in getting the most information from each study.

Our histologists and pathologists have many combined years of experience in all laboratory animals including but not limited to:

Non-human primate
Porcine
Canine
Rabbit
Guinea pig
Rat
Mouse
Zebra fish

Our pathologists will work with you and provide to you the appropriate type of pathology report to fit your needs.  MHS offers various types of pathology reports:

DESCRIPTIVE: A descriptive pathology report is a narrative report in which the veterinary pathologist will describe, in detail, any abnormality (pathology) seen within the specimen on the microscope slide. This type of report is often used for diagnostic histopathology and efficacy results. Here is an example of a typical descriptive pathology report.

TOXICOLOGY: A toxicology report is a semi-quantitative pathology report in which the veterinary pathologist will review a set of target organs from groups of animals and report any abnormalities seen. Any pathological condition (inflammation, necrosis, fibrosis, etc.) is then scored on its severity (1 = mild to 3 = severe). This type of report is often used for the toxicity of a compound or efficacy results.

SEMI-QUANTITATIVE: A semi-quantitative pathology report is a pathology report in which the veterinary pathologist will review a set of specimens and score specific conditions specific to the client's research. Each criteria (inflammation, necrosis, fibrosis, etc.) is scored on its severity (1 = mild to 3 = severe). This type of report is often used for efficacy studies.

QUANTITATIVE: A quantitative pathology report is a report in which the veterinary pathologist will utilize computer-generated digital images of the client’s slides. Using various filters and colors, certain cell types can be isolated and quantified for exact quantities. For example, quantitative reports can obtain percentages (“12% of the total tissue mass consists of fibrosis”) or sizes (“The average islet size seen within this pancreas measures 84 microns in diameter and range from 24 to 197 microns in diameter”). This type of report is often used for very accurate measurements and not just ranges.

COMPREHENSIVE: A comprehensive pathology report is a report in which the veterinary pathologist will provide the researcher with a descriptive report which also includes semi-quantitative data, data analysis, annotated photographs and conclusions. This type of report is often requested for GLP studies.

CUSTOM: If none of the above reports fits your needs, Mass Histology Service will custom make a report which will answer all of your questions. For example, we have combined descriptive and semi-quantitative reports as seen in this example. We will work with you and come up with any type of report

Histology Services:  Just need slides made of your specimens for your pathologist to review?  MHS can trim in your tissues (or process your cassettes) to paraffin blocks, section, stain (H&E, "special" or IHC) and send the finished microscope slides back to you for you to review.  All slides will be permanently labeled with the experiment number, animal number and tissue code.  The slides will be packed securely in special transport/storage slide boxes.  The outside of the slide boxes will be labeled with your experiment number for your convenience during archiving.

On-site Necropsy Services:  Many of our histologists have years of experience  in necropsy techniques and can travel to your site to assist you if needed.  We have experience in both large and small necropsy techniques.